4-(difluoromethoxy)benzoic acid

4-(difluoromethoxy)benzoic acid - Names and Identifiers

Name	4-(difluoromethoxy)benzoic acid
Synonyms	AKOS B006807 RARECHEM AL BO 0735 TIMTEC-BB SBB003678 4-(difluoromethoxy)benzoate 4-(DIFLUOROMETHOXY)BENZOIC ACID P-(DIFLUOROMETHOXY)BENZOIC ACID 4-(difluoromethoxy)benzoic acid 4-(Difluorome4-(Difluoromethoxy)benzoic acidthoxy)benzoic acid
CAS	4837-20-1
EINECS	625-589-7
InChI	InChI=1/C8H6F2O3/c9-8(10)13-6-3-1-5(2-4-6)7(11)12/h1-4,8H,(H,11,12)/p-1

4-(difluoromethoxy)benzoic acid - Physico-chemical Properties

Molecular Formula	C8H6F2O3
Molar Mass	188.13
Density	1.370±0.06 g/cm3(Predicted)
Melting Point	169-171 °C (lit.)
Boling Point	272.1±30.0 °C(Predicted)
Flash Point	118.3°C
Vapor Presure	0.00304mmHg at 25°C
BRN	2615223
pKa	4.02±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
MDL	MFCD00221454

4-(difluoromethoxy)benzoic acid - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
HS Code	29189900
Hazard Class	IRRITANT

4-(difluoromethoxy)benzoic acid - Introduction

4-(difluoromethoxy)benzoic acid is an organic compound with the chemical formula C8H6F2O3. It is a colorless to pale yellow solid with a peculiar odor.

One of the main uses of this compound is as a pharmaceutical intermediate. It can be used to synthesize anti-inflammatory, analgesic and anti-tuberculosis drugs. In addition, it can also be used as a raw material for paints and dyes.

The method for preparing 4-(difluoromethoxy)benzoic acid is mainly obtained by reacting 3,4-difluoroanisole with carbon dioxide. The specific synthesis process can be carried out by different methods, such as using an ether solvent to catalyze the reaction, or using a gas phase method to carry out the reaction.

As with any chemical, safety precautions are required when using and handling 4-(difluoromethoxy)benzoic acid. It is an irritating chemical, and inhalation of its dust or gas should be avoided. Wear appropriate protective equipment such as goggles and chemical protective gloves during operation. When storing and handling compounds, care should be taken to avoid high temperatures and open flames, and to store them in sealed containers, away from acids, alkalis, and oxidants. During use and handling, it is necessary to follow appropriate procedures and safe operating procedures. In the laboratory, it is recommended to use the compound under the guidance of a professional.

Last Update：2024-04-09 20:52:54